Hypoxia | Vasopressors for Cerebral Oxygenation
Hypoxia research study
What is the primary objective of this study?
Liberal fluid administration is one of risk factors of developing acute lung injury (ALI) in thoracic surgery. Therefore, the investigators try to restrain fluid administration, and in the case of intraoperative hypotension, the investigators often administer vasoactive agents or inotropes. One lung ventilation (OLV) which is routinely employed for thoracic surgery decrease arterial oxygenation and oxygen delivery to brain can be also decreased. In this study, the investigators compared dopamine and phenylephrine in respect to maintaining cerebral oxygen saturation in major thoracic surgery. The investigators hypothesis is that dopamine is better than phenylephrine to maintain cerebral oxygen saturation in thoracic surgery.
Who is eligible to participate?
Inclusion Criteria: - Elective surgery - American society of anesthesia physical status I-III Exclusion Criteria: - Symptomatic cardiovascular disease - Poorly controlled hypertension (systolic arterial pressure ≥160 mm Hg) - Cerebrovascular disease - Poorly controlled diabetes mellitus (blood glucose ≥200 mg/dl) - Diuretics or antidepressant use before operation - Renal insufficiency (creatinine>1.5 mg/dl) - Cerebral infarction - Documented coagulopathy
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:dopaminecontinuous infusion during operation
Drug:phenylephrinecontinuous infusion of phenylephrine during operation
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
dopaminedopamine is administered to maintain systolic blood pressure in the range of 80-120% of baseline during operation
phenylephrinePhenylephrine is administered to maintain systolic blood pressure in the range of 80-120% of baseline during operation
Start Date: December 2012
Completed Date: December 2014
Phase: Phase 1
Primary Outcome: Cerebral oximeter reading
Secondary Outcome: cardiac output
Study sponsors, principal investigator, and references
Principal Investigator: Hyun Joo Ahn
Lead Sponsor: Samsung Medical Center