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Hypoxia | Vasopressors for Cerebral Oxygenation

Hypoxia research study

What is the primary objective of this study?

Liberal fluid administration is one of risk factors of developing acute lung injury (ALI) in thoracic surgery. Therefore, the investigators try to restrain fluid administration, and in the case of intraoperative hypotension, the investigators often administer vasoactive agents or inotropes. One lung ventilation (OLV) which is routinely employed for thoracic surgery decrease arterial oxygenation and oxygen delivery to brain can be also decreased. In this study, the investigators compared dopamine and phenylephrine in respect to maintaining cerebral oxygen saturation in major thoracic surgery. The investigators hypothesis is that dopamine is better than phenylephrine to maintain cerebral oxygen saturation in thoracic surgery.

Who is eligible to participate?

Inclusion Criteria: - Elective surgery - American society of anesthesia physical status I-III Exclusion Criteria: - Symptomatic cardiovascular disease - Poorly controlled hypertension (systolic arterial pressure ≥160 mm Hg) - Cerebrovascular disease - Poorly controlled diabetes mellitus (blood glucose ≥200 mg/dl) - Diuretics or antidepressant use before operation - Renal insufficiency (creatinine>1.5 mg/dl) - Cerebral infarction - Documented coagulopathy

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Hypoxia

Hypotension

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:dopaminecontinuous infusion during operation

Drug:phenylephrinecontinuous infusion of phenylephrine during operation

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

dopaminedopamine is administered to maintain systolic blood pressure in the range of 80-120% of baseline during operation

phenylephrinePhenylephrine is administered to maintain systolic blood pressure in the range of 80-120% of baseline during operation

Study Status

Unknown status

Start Date: December 2012

Completed Date: December 2014

Phase: Phase 1

Type: Interventional

Design:

Primary Outcome: Cerebral oximeter reading

Secondary Outcome: cardiac output

Study sponsors, principal investigator, and references

Principal Investigator: Hyun Joo Ahn

Lead Sponsor: Samsung Medical Center

Collaborator:

More information:https://clinicaltrials.gov/show/NCT02009007

Discuss Dopamine