Obesity | Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans

Obesity research study

What is the primary objective of this study?

The investigators hypothesize that some of these changes in the reduced appetite after surgery may be due to alterations in taste. The aim is to compare obese patients before and after bariatric surgery (gastric bypass and banding) to define the reward value of sweet, fatty and vegetable/fruit taste in obese individuals, and how this changes after surgery.

Who is eligible to participate?

Inclusion Criteria: - BMI of 18-25 for normal weight volunteers - BMI of >30 for obese patients Exclusion Criteria: - Pregnancy - breast feeding - substance abuse - consumption of more than 3 alcoholic units per day - severe psychiatric illness - lack of understanding of test instructions - diabetes mellitus - chronic medical conditions making a general anaesthetic unsafe - allergy to stimulus ingredients - active smoking

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?


Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

ControlNormal weight healthy volunteers

Gastric bandingobese patients undergoing gastric banding obesity surgery

Gastric bypassobese patients due to undergo gastric bypass surgery

Study Status

Unknown status

Start Date: July 2010

Completed Date: August 2018


Type: Observational


Primary Outcome: Breakpoints

Secondary Outcome: Hunger

Study sponsors, principal investigator, and references

Principal Investigator: Carel W le Roux, MRCP PhD

Lead Sponsor: Imperial College London

Collaborator: Medical Research Council

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