Obesity | Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans
Obesity research study
What is the primary objective of this study?
The investigators hypothesize that some of these changes in the reduced appetite after surgery may be due to alterations in taste. The aim is to compare obese patients before and after bariatric surgery (gastric bypass and banding) to define the reward value of sweet, fatty and vegetable/fruit taste in obese individuals, and how this changes after surgery.
Who is eligible to participate?
Inclusion Criteria: - BMI of 18-25 for normal weight volunteers - BMI of >30 for obese patients Exclusion Criteria: - Pregnancy - breast feeding - substance abuse - consumption of more than 3 alcoholic units per day - severe psychiatric illness - lack of understanding of test instructions - diabetes mellitus - chronic medical conditions making a general anaesthetic unsafe - allergy to stimulus ingredients - active smoking
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
ControlNormal weight healthy volunteers
Gastric bandingobese patients undergoing gastric banding obesity surgery
Gastric bypassobese patients due to undergo gastric bypass surgery
Start Date: July 2010
Completed Date: August 2018
Primary Outcome: Breakpoints
Secondary Outcome: Hunger
Study sponsors, principal investigator, and references
Principal Investigator: Carel W le Roux, MRCP PhD
Lead Sponsor: Imperial College London
Collaborator: Medical Research Council