PatientsVille.com LogoPatientsVille.com

Primary Ciliary Dyskinesia | Otolith Function in Patients With Primary Ciliary Dyskinesia

Primary Ciliary Dyskinesia research study

What is the primary objective of this study?

The purpose of this study is to determine whether patients with primary ciliary dyskinesia (PCD) have reduced or absent otolith function.The otolith system is a specific part of the inner ear vestibular (balance) system that detects linear movement.

Who is eligible to participate?

Inclusion Criteria: - aged 16-30 years - Confirmed diagnosis of PCD under the care of the PCD team at the Royal Brompton Hospital Exclusion Criteria: - Aged under 16 years - Unconfirmed or \"suspected\" PCD - Previous history of balance disorders or diagnoses - Previous history of sensorineural hearing loss - Previous middle or inner ear surgery (other than grommet insertion)

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Primary Ciliary Dyskinesia

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:Vestibular evoked myogenic potentials (VEMPs)Standard test of balance function

Other:Utricular centrifugation testStandard test of balance function

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Test groupStandard tests of balance function

Study Status

Completed

Start Date: September 2010

Completed Date: December 2013

Phase:

Type: Observational

Design:

Primary Outcome: Vestibular Evoked Myogenic Potentials (VEMPs)

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Joanne Rimmer, MA FRCS

Lead Sponsor: Imperial College Healthcare NHS Trust

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01246258

Rimmer J, Patel M, Agarwal K, Hogg C, Arshad Q, Harcourt J. Peripheral vestibular dysfunction in patients with primary ciliary dyskinesia: abnormal otoconial development? Otol Neurotol. 2015 Apr;36(4):662-9. doi: 10.1097/MAO.0000000000000592.

Discuss Dyskinesia