Primary Ciliary Dyskinesia | Chest Physiotherapy and Lung Function in Primary Ciliary Dyskinesia

Primary Ciliary Dyskinesia research study

What is the primary objective of this study?

Primary ciliary dyskinesia (PCD) is a rare disease, caused by impairment of the motile cilia. Patients present with chronic upper and lower respiratory tract infections. The therapy is mainly supportive and based on that of cystic fibrosis. Chest physiotherapy is one of the cornerstones of the therapy, however the influence of chest physiotherapy on lung function (short term and long term) is not clear. For interpretation of longitudinal lung function data it is important to examine the short time effect of chest physiotherapy. We hypothesize that a session of chest physiotherapy improves lung function and that thus lung function tests must be performed in a standardized way.

Who is eligible to participate?

Inclusion Criteria: - Primary ciliary dyskinesia - able to perform spirometry and MBW (>6 years) Exclusion Criteria: - acute exacerbation

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Primary Ciliary Dyskinesia

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Procedure:Chest physiotherapy20 minutes of chest physiotherapy by physiotherapist

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

chest physiotherapysession of 20 minutes chest physiotherapy with physiotherapist, use of airway clearance techniques, PEP (positive expiratory pressure) device

Study Status


Start Date: October 2013

Completed Date: November 2017

Phase: N/A

Type: Interventional


Primary Outcome: Difference in FEV1 before and after treatment

Secondary Outcome: Difference in LCI before and after chest physiotherapy

Study sponsors, principal investigator, and references

Principal Investigator: Mieke Boon, MD

Lead Sponsor: Universitaire Ziekenhuizen Leuven


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