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Dysphagia | Dysphagia in Oculopharyngeal Muscular Dystrophy (OPMD)- Evaluation, Endoscopic Examination of Swallowing, Treatment and Long Term Follow up

Dysphagia research study

What is the primary objective of this study?

The investigators aimed to review the natural history of dysphagia and dysphonia in OPMD in order to identify the best candidates and the proper timing to perform dysphagia alleviating procedures in both heterozygote and homozygote patients from the large pool of cases with this disease in Israel.

Who is eligible to participate?

Inclusion Criteria: - heterozygote and homozygote OPMD patients Exclusion Criteria:

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Dysphagia

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Procedure:Upper esophageal sphincter myotomyUpper esophageal sphincter release operation to allow better swallowing. The intervention is done under GA and by extra-mucosal approach.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Mild dysphagia

Severe dysphagia

Study Status

Unknown status

Start Date: July 2009

Completed Date:

Phase: Phase 1

Type: Interventional

Design:

Primary Outcome: Dysphagia, quality of life. Proper intervention timing in OPMD based on knowledge about the natural history of the feeding difficulty.

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: Hillel Yaffe Medical Center

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01167439

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