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Fatigue | Fatigue Before and After Exercise in Patients With Advanced Cancer Stage

Fatigue research study

What is the primary objective of this study?

Fatigue related to cancer is the most common reported symptom and it prevents 91% of patients of having an active life, and in several cases, the fatigue persists for several months or even years after treatment. Fatigue does cause an impact in all dimensions of patients' quality of life and it is the main cause of reduction in patients' daily life activities. Fatigue is reported by cancer patients in all phases of the illness as one of the most frequent symptoms, especially in cases presenting metastases. In order to monitor fatigue, pharmacological and non-pharmacological techniques may be employed, such as physical activity. Physical exercise has shown positive results in mitigating fatigue improving cardiopulmonary functioning, physical capacity and patients' quality of life. This study will assess the efficiency of physical activity upon controlling the fatigue and quality of life in patients with advanced stage of the disease at the end of 7 days using FACT-F subscale.

Who is eligible to participate?

Inclusion Criteria: - Be older than 18 years of age, - Any gender - Able to understand the study protocol, - Functional capacity equal to or higher than 60, according to the Karnofsky scale, - Patients with a life expectancy between 3 and 12 months, - Patient able to ambulate independently without need for any orthotics. Exclusion Criteria: - Patients that use drugs in order to control fatigue (Methylphenidate, Modafinil), - Anemic Patients (HB< 8.0 mg/dl), - Patients with cognitive deficit, - Uncontrolled pain higher than 5, according to Visual Analogue Scale (VAS), - Patients currently exercising, - Patients with congestive heart failure (CHF) (New York Heart Association functional class III or IV) or related angina.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Fatigue

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:10 minute walkPatients who walk a distance ≤ 300 meters in the 6-minute walk test will make a 10 minute walk once a day for 5 days for 4 weeks in a 90-feet long corridor located at the palliative care unit.

Other:20 minute walkPatients who walk 300-450 meters in the 6-minute walk test will make a 20 minute walk once a day for 5 days for 4 weeks in a 90-feet long corridor located at the palliative care unit.

Other:30 minute walkPatients who walk a distance less than 450 meters in the 6-minute walk test will make a 30 minute walk once a day for 5 days for 4 weeks in a 90-feet long corridor located at the palliative care unit.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

10 minute walk10-minute walk and exercises for the upper limbs with 1 lb-dumbbells

20 minute walk20-minute walk and exercises for the upper limbs with 1 lb-dumbbells

30 minute walk30-minute walk and exercises for the upper limbs with 1 lb-dumbbells

Study Status

Unknown status

Start Date: December 2011

Completed Date: December 2016

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Fatigue

Secondary Outcome: Quality of life

Study sponsors, principal investigator, and references

Principal Investigator: Adriana M Ferreira, PhD

Lead Sponsor: Barretos Cancer Hospital

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01581216

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