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Periodontitis | The Impact of Obesity on Nonsurgical Periodontal Therapy

Periodontitis research study

What is the primary objective of this study?

The purpose of this study is to investigate the effect that obesity may have on the nonsurgical treatment (with and without the adjunct use of metronidazole) of destructive periodontal diseases (chronic periodontitis).

Who is eligible to participate?

Inclusion Criteria: - Normal weight or obese (according to BMI) - nonsmokers or former smokers (3 or more years) - no systemic diseases that may affect periodontal treatment (diabetes, osteoporosis, steroid use) - have 10 teeth present - have at least 2 teeth with probing depth 6+mm and attachment loss 4+mm Exclusion Criteria: - Pregnancy - Development of diabetes or other conditions that may impair periodontal healing

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Periodontitis

Periodontal Diseases

Obesity

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:MetronidazoleMetronidazole 400mg TID for 10 days

Drug:PlaceboPlacebo pill TID for 10 days

Procedure:Scaling and root planningScaling and root planning performed with curettes and ultrasonic scalers under local anesthesia

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Metronidazole

Placebo

Study Status

Unknown status

Start Date: August 2009

Completed Date: December 2012

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Probing depth

Secondary Outcome: Attachment level

Study sponsors, principal investigator, and references

Principal Investigator: Cassiano K Rosing, DDS, PhD

Lead Sponsor: Federal University of Rio Grande do Sul

Collaborator: Augusta University

More information:https://clinicaltrials.gov/show/NCT01405365

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