Periodontitis | The Impact of Obesity on Nonsurgical Periodontal Therapy
Periodontitis research study
What is the primary objective of this study?
The purpose of this study is to investigate the effect that obesity may have on the nonsurgical treatment (with and without the adjunct use of metronidazole) of destructive periodontal diseases (chronic periodontitis).
Who is eligible to participate?
Inclusion Criteria: - Normal weight or obese (according to BMI) - nonsmokers or former smokers (3 or more years) - no systemic diseases that may affect periodontal treatment (diabetes, osteoporosis, steroid use) - have 10 teeth present - have at least 2 teeth with probing depth 6+mm and attachment loss 4+mm Exclusion Criteria: - Pregnancy - Development of diabetes or other conditions that may impair periodontal healing
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:MetronidazoleMetronidazole 400mg TID for 10 days
Drug:PlaceboPlacebo pill TID for 10 days
Procedure:Scaling and root planningScaling and root planning performed with curettes and ultrasonic scalers under local anesthesia
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Start Date: August 2009
Completed Date: December 2012
Primary Outcome: Probing depth
Secondary Outcome: Attachment level
Study sponsors, principal investigator, and references
Principal Investigator: Cassiano K Rosing, DDS, PhD
Lead Sponsor: Federal University of Rio Grande do Sul
Collaborator: Augusta University