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Postoperative Ileus | Effect of Sham Feeding on Postoperative Ileus After Elective Liver Transplantation

Postoperative Ileus research study

What is the primary objective of this study?

Postoperative ileus is a common after abdominal surgery. Multifactorial etiology such as surgical trauma, bowel manipulation and perioperative opioids contributes to delayed return of normal gut function Chewing gum has recently been used as a form of sham feeding to stimulate acceleration of gut function after abdominal surgery. The investigators hypothesize that sham feeding with chewing gum will accelerate return of gut function after liver transplantation.

Who is eligible to participate?

Inclusion Criteria: - elective liver transplantation surgery - an ability to chew gum Exclusion Criteria: - emergency surgery - age less than 18 years, - inability to provide written informed consent - an inability to chew gum - hepaticojejunostomy - sedated patients - reintubated patients - Glasgow Coma Scale <13 - reoperation before gas out - previous bowel surgery

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Postoperative Ileus

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:gum chewinggum chewing

Other:ControlRoutine care during NPO

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

gum chewingGum type was standardized with all subjects receiving sugar-free xylitol gum. The patients in the chewing gum group, gum chewing began the morning of postoperative day 1. Patients chewed gum (two tablets) 3 times daily in the morning, afternoon, and evening for 15 min. The administration of the therapy was implemented by ICU nurses and recorded in the clinical report form file. All gum-chewing patients completed their course of gum chewing until gas out.

ControlRoutine care during NPO

Study Status

Completed

Start Date: October 2013

Completed Date: September 2014

Phase: Phase 4

Type: Interventional

Design:

Primary Outcome: time to flatus

Secondary Outcome: percentage of target calories

Study sponsors, principal investigator, and references

Principal Investigator: Hogeol Ryu, MD. PhD.

Lead Sponsor: Seoul National University Hospital

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01956643

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