Abdominal Abscess | Treatment of Abdominal Abscesses With or Without Fibrinolysis
Abdominal Abscess research study
What is the primary objective of this study?
The objective of this study is to evaluate the utility of fibrinolysis when draining an abdominal abscess as defined by length of stay after drainage.
Who is eligible to participate?
Inclusion Criteria: - Patients under age 18 found to have an abscess in their abdomen related to perforated appendicitis that requires a drain either prior to or after appendectomy. Exclusion Criteria: - Patients with known immune deficiency per medical record review - Patients with another condition affecting surgical decision making or recovery - Patients with drain unable to be placed
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Tissue Plasminogen Activator
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Procedure:Tissue plasminogen activator abscess flushThirteen ml of 10% tPA in saline at time of drain and twice daily thereafter.
Procedure:Saline flush of abscessThirteen ml of saline is used to flush abscess at time of drain placement and twice daily thereafter.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Saline only flush of abscessSaline alone used to flush abscess
Saline plus tPA flush of abscessSaline plus tPA used for abscess flush
Start Date: June 2009
Completed Date: May 2014
Primary Outcome: Length of hospital stay
Study sponsors, principal investigator, and references
Principal Investigator: Shawn D St. Peter, MD
Lead Sponsor: Children's Mercy Hospital Kansas City