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Abdominal Abscess | Treatment of Abdominal Abscesses With or Without Fibrinolysis

Abdominal Abscess research study

What is the primary objective of this study?

The objective of this study is to evaluate the utility of fibrinolysis when draining an abdominal abscess as defined by length of stay after drainage.

Who is eligible to participate?

Inclusion Criteria: - Patients under age 18 found to have an abscess in their abdomen related to perforated appendicitis that requires a drain either prior to or after appendectomy. Exclusion Criteria: - Patients with known immune deficiency per medical record review - Patients with another condition affecting surgical decision making or recovery - Patients with drain unable to be placed

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Abdominal Abscess

Tissue Plasminogen Activator

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Procedure:Tissue plasminogen activator abscess flushThirteen ml of 10% tPA in saline at time of drain and twice daily thereafter.

Procedure:Saline flush of abscessThirteen ml of saline is used to flush abscess at time of drain placement and twice daily thereafter.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Saline only flush of abscessSaline alone used to flush abscess

Saline plus tPA flush of abscessSaline plus tPA used for abscess flush

Study Status

Completed

Start Date: June 2009

Completed Date: May 2014

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Length of hospital stay

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Shawn D St. Peter, MD

Lead Sponsor: Children's Mercy Hospital Kansas City

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01597336

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