Hot Flashes | Health Effects of Resistance Training on Postmenopausal Women

Hot Flashes research study

What is the primary objective of this study?

Today's women will live more than a third of their lives after menopause, i.e. with a changed hormonal and metabolic state. Vasomotor symptoms like hot flushes and sweating are reported by about 75% of all women around menopause and may impair well-being, mental state, daily activities and night sleep. Vasomotor symptoms are less prevalent in women who participate in regular physical exercise. It is, however, still uncertain if physical exercise reduces vasomotor symptoms. The purpose of this randomized controlled study is to establish possible beneficial health effects from 15 weeks of supervised resistance training (RT) on postmenopausal women. End-points include effects from RT in postmenopausal women on 1. clinical outcomes (number and severity of vasomotor symptoms, Health-Related quality of Life (HRQoL), Body Mass Index (BMI), abdominal height, muscle strength and mass, browning of fat), 2. diagnostic variables (production of myokines as irisin, immunological markers) and 3. genetic variables (length of telomeres). The control group will be offered resistance training after the intervention period.

Who is eligible to participate?

Inclusion Criteria: - Postmenopausal women who had at least 28 moderate to severe hot flashes per week during a screening period of two weeks.(Postmenopausal, i.e. had their last menstrual bleeding at least 12 months ago or have increased gonadotrophic hormones showing they are postmenopausal.) - At lest 45 years of age - Good physical health and physical ability to take part in organized resistance training or other training at least three times per week. - Ability to speak and read Swedish - Freely informed consent for participation Exclusion Criteria: - Physically active more than 75 minutes of intense exercise per week or more than 150 minutes of low intensity activities - Hb <110 g/l - Blood pressure >160 systolic and/or >100 mmHg diastolic pressure - Ongoing usage or use during the last two months of hormone therapy aimed for hot flashes - Treatment with psychopharmacological drugs (e.g SSRI or SNRI) or other treatment with a possible effect on menopausal symptoms - Uninvestigated or unstable disease that could affect presence of flushes (e.g thyroid disease) - Other medical condition that is judged inappropriate to combine with physical activity or participation in the study.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Hot Flashes


Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:Resistance trainingResistance training supervised and individualized by an experienced physiotherapist. First the relative load will be lighter during three weeks, thereafter the intensity and load will be increased over another 12 weeks.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Resistance trainingThe resistance training will be supervised and individualized by an experienced physiotherapist. First the relative load will be lighter during three weeks, thereafter the intensity and load will be increased over another 12 weeks.

Control groupNo intervention for 15 weeks but the same registrations, diaries and forms as the intervention group. The control group will however be omitted from muscle strength testing.

Study Status

Active, not recruiting

Start Date: November 2013

Completed Date: June 2019

Phase: N/A

Type: Interventional


Primary Outcome: Change in frequency of hot flushes per 24 h

Secondary Outcome: Health-related quality of life (HRQoL)

Study sponsors, principal investigator, and references

Principal Investigator: Mats L Hammar, Professor

Lead Sponsor: Ostergotland County Council, Sweden

Collaborator: Linkoeping University

More information:

Dahlqvist Leinhard O, Johansson A, Rydell J, Smedby Ö, Nyström F, Lundberg P, Borga M. Quantitative Abdominal Fat Estimation Using MRI. 2008 19th International Conference on Pattern Recognition, ICPR 2008 , art. no. 4761764.

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