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Depressive Disorder | Pharmacotherapy and Psychotherapy for MDD After Remission on Psychology and Neuroimaging

Depressive Disorder research study

What is the primary objective of this study?

The purpose of this study is to determine the level of residual symptoms and psychosocial factors affecting recovery of psychosocial functions in MDD patients who reach remission, and investigate the recovery process of psychosocial functions. The investigators suppose that even the patient is well-treated by drug,there are still many residual symptoms,and they also exist different degree of damage in the structure and functions of brain. CBT could help them obtain better recovery,especially in psychosocial functions.

Who is eligible to participate?

Inclusion Criteria: - Clinical diagnosis of major depressive disorder (MDD) - Hamilton Rating Scale for Depression(HAMD) less than 7 Exclusion Criteria: - Bipolar disorder - Substance dependence - Neurological disorder or other mental disorder - Severe body disease

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Depressive Disorder

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Behavioral:medicine combined CBTmedicine:Clinical routine antidepressant treatment CBT:During the treatment period,weekly for 8 weeks,and monthly for the maintenance phase.Therapists receive group supervision monthly.

Drug:medicineParticipants receive only clinical routine antidepressant treatment,Which include fluoxetine (Prozac); sertraline (Zoloft); paroxetine (Paxil); citalopram (Celexa) ;escitalopram (Lexapro) and fluvoxamine (Luvox). It will be chosen according to special condition of every patient.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

medicine combined CBTBesides clinical routine antidepressant treatment,participants receive CBT weekly for 8 weeks and monthly until the end of the study.

medicine (SSRI antidepressants)clinical routine antidepressant treatment——Selective serotonin reuptake inhibitors(SSRIs).

Study Status

Unknown status

Start Date: January 2011

Completed Date: December 2014

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Hamilton Rating Scale for Depression (HAMD)

Secondary Outcome: Magnetic Resonance Imaging

Study sponsors, principal investigator, and references

Principal Investigator: Zhang Ning

Lead Sponsor: Nanjing Medical University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01831440

Mattisson C, Bogren M, Horstmann V, Munk-Jörgensen P, Nettelbladt P. The long-term course of depressive disorders in the Lundby Study. Psychol Med. 2007 Jun;37(6):883-91. Epub 2007 Feb 19.

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