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Upper Extremity Surgery | A Comparison of Ropivacaine Alone Versus Combination of Dexamethasone and Clonidine for Block

Upper Extremity Surgery research study

What is the primary objective of this study?

The aim of this randomized, observer-blinded study is to evaluate the postoperative analgesic efficacy of adding dexamethasone and clonidine to ropivacaine in supraclavicular nerve block. The investigators hypothesized that addition of dexamethasone and clonidine to ropivacaine would prolong the duration of analgesia in supraclavicular nerve block compared with ropivacaine alone.

Who is eligible to participate?

Inclusion Criteria: - Men and women 18-80 years old - Undergoing upper extremity surgery - Receiving Supraclavicular block - Receiving ropivacaine, ropivacaine adjuvants (dexamethasone, clonidine) for the supraclavicular nerve block. - Able to give Informed consent Exclusion Criteria: - Age less than 18 and greater than 80 years - Inability to understand the study procedures - Significant respiratory dysfunction - Preexisting neurologic deficits - Allergy to local anesthetics - A bleeding diathesis or on anticoagulants - Systemic glucocorticoid use - Refuse to participate in the study

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Upper Extremity Surgery

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:RopivacaineRopivacaine alone

Drug:Ropivacaine and dexamethasoneRopivacaine combination with dexamethasone

Drug:Ropivacaine and clonidineRopivacaine combination with clonidine

Drug:Ropivacaine, dexamethasone and clonidineRopivacaine combination with dexamethasone and clonidine

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

RopivacaineRopivacaine 0.5% 25 ml alone for supraclavicular block

Ropivacaine and dexamethasone25 ml 0.5% ropivacaine + 4 mg dexamethasone

Ropivacaine and clonidine25 ml 0.5% ropivacaine + 100 mcg clonidine

Ropivacaine, dexamethasone and clonidine25 ml 0.5% ropivacaine + 4 mg dexamethasone + 100 mcg clonidine

Study Status

Completed

Start Date: March 2014

Completed Date: August 20, 2016

Phase:

Type: Observational

Design:

Primary Outcome: Duration of the Sensorial Supraclavicular Block

Secondary Outcome: Postoperative Analgesia

Study sponsors, principal investigator, and references

Principal Investigator: Dawood Nasir, MD

Lead Sponsor: University of Texas Southwestern Medical Center

Collaborator:

More information:https://clinicaltrials.gov/show/NCT02151487

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