Upper Extremity Surgery | A Comparison of Ropivacaine Alone Versus Combination of Dexamethasone and Clonidine for Block
Upper Extremity Surgery research study
What is the primary objective of this study?
The aim of this randomized, observer-blinded study is to evaluate the postoperative analgesic efficacy of adding dexamethasone and clonidine to ropivacaine in supraclavicular nerve block. The investigators hypothesized that addition of dexamethasone and clonidine to ropivacaine would prolong the duration of analgesia in supraclavicular nerve block compared with ropivacaine alone.
Who is eligible to participate?
Inclusion Criteria: - Men and women 18-80 years old - Undergoing upper extremity surgery - Receiving Supraclavicular block - Receiving ropivacaine, ropivacaine adjuvants (dexamethasone, clonidine) for the supraclavicular nerve block. - Able to give Informed consent Exclusion Criteria: - Age less than 18 and greater than 80 years - Inability to understand the study procedures - Significant respiratory dysfunction - Preexisting neurologic deficits - Allergy to local anesthetics - A bleeding diathesis or on anticoagulants - Systemic glucocorticoid use - Refuse to participate in the study
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Upper Extremity Surgery
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:Ropivacaine and dexamethasoneRopivacaine combination with dexamethasone
Drug:Ropivacaine and clonidineRopivacaine combination with clonidine
Drug:Ropivacaine, dexamethasone and clonidineRopivacaine combination with dexamethasone and clonidine
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
RopivacaineRopivacaine 0.5% 25 ml alone for supraclavicular block
Ropivacaine and dexamethasone25 ml 0.5% ropivacaine + 4 mg dexamethasone
Ropivacaine and clonidine25 ml 0.5% ropivacaine + 100 mcg clonidine
Ropivacaine, dexamethasone and clonidine25 ml 0.5% ropivacaine + 4 mg dexamethasone + 100 mcg clonidine
Start Date: March 2014
Completed Date: August 20, 2016
Primary Outcome: Duration of the Sensorial Supraclavicular Block
Secondary Outcome: Postoperative Analgesia
Study sponsors, principal investigator, and references
Principal Investigator: Dawood Nasir, MD
Lead Sponsor: University of Texas Southwestern Medical Center