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Alveolar Bone Healing After Dental Extraction | Bone Healing After Dental Extraction in Postmenopausal Osteoporotic Women Treated With Alendronate Per os Weekly

Alveolar Bone Healing After Dental Extraction research study

What is the primary objective of this study?

The purpose of this study is to determine whether the oral alendronate treatment of post-menopausal osteoporosis could be a risk factor for jaw bone healing after dental extraction.

Who is eligible to participate?

Inclusion Criteria: - Postmenopausal osteoporotic women - Treated with alendronate per os (70 pg weekly) for BP+ experimental group and untreated with this therapy for the BP - Control group - Subjected to single root tooth extraction- 45 to 70 years of age Exclusion Criteria: - Maxillofacial irradiations - Dental extraction with adjunction of material interfering with bone healing - Severe pathologies inconsistent with this study - Bisphosphonate treatment for BP- control group - Women treated with denosumab (prolia®) - Women already included to an another dental extraction

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Alveolar Bone Healing After Dental Extraction

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Procedure:Dental extraction3 dental radiographies realised immediately, then 30 days, then 90 days after dental extraction

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Women treated by bisphosphonatePostmenopausal osteoporotic women treated by alendronate 70 mg weekly per os

Women didn't treat by bisphosphonatePostmenopausal osteoporotic women untreated by bisphosphonates

Study Status

Completed

Start Date: September 19, 2012

Completed Date: November 5, 2015

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Alveolar socket filled by new bone

Secondary Outcome: Mucosal injury

Study sponsors, principal investigator, and references

Principal Investigator: Christian ROUX, MD, PhD

Lead Sponsor: Assistance Publique - H├┤pitaux de Paris

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01648686

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