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Intraarticular Fracture and Post-traumatic Osteoarthritis | Inflammatory Response Following Intraarticular Fracture

Intraarticular Fracture and Post-traumatic Osteoarthritis research study

What is the primary objective of this study?

The purpose of the study is to investigate a relationship between the inflammatory response following intraarticular fracture and post-traumatic osteoarthritis. The investigators plan to evaluate the inflammatory cytokine profile in knee joint synovial fluid and blood serum in patients who sustain an intraarticular tibial plateau fracture and ankle joint synovial fluid and blood serum in patients who sustain an intraarticular tibial plafond fracture. This information will be combined with radiographs and patient outcome measures to determine a correlation between intraarticular inflammatory response and post-traumatic osteoarthritis.

Who is eligible to participate?

Inclusion Criteria: - 18 years of age or older - Radiographic evidence of tibial plateau fracture Exclusion Criteria: - Less than 18 years of age - Greater than 60 years of age - Any history of pre-existing knee osteoarthritis based on previous diagnosis or suggestive history - Any history of autoimmune disease - Any history of contralateral intra-articular knee injury

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Intraarticular Fracture and Post-traumatic Osteoarthritis

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

tibial plateau or plafond fractureTibial plateau or plafond fracture based on radiographs and/or CT scan will have synovial fluid aspirated from both the injured and uninjured joints in either the operating room if a procedure is planned for within 24 hours or in the emergency department. While the patient is under anesthesia in the operating room, the investigators will obtain blood samples.

Study Status

Recruiting

Start Date: October 2011

Completed Date: December 2019

Phase:

Type: Observational

Design:

Primary Outcome: Post-traumatic osteoarthritis (PTOA)

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Justin Haller, MD

Lead Sponsor: University of Utah

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01514643

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