Hyperalgesia | Effect of Gabapentin on Pain of the Second Cataract Surgery
Hyperalgesia research study
What is the primary objective of this study?
Gabapentin pretreatment may reduce hyperalgesia occurring at the second surgery in serial, bilateral cataract surgery.
Who is eligible to participate?
Inclusion Criteria: - Patient of ASA(American Cociety of Anesthesiology) class I, II, III between age 20 to 80, scheduled for serial bilateral cataract surgery(1 weel interval) Exclusion Criteria: - refuse to participate - BMI<16 or BMI >30 - severe cardiovascular, pulmonary, renal disease - alcohol or drug abuse - currently taking CNS(central nervous system) inhibitory drugs - taking antiacids - depressive disorder pregnancy
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:gabapentin100 mg tid of gabapentin is prescribed to the patient for 1 week after the first eye surgery
Drug:placebothe same regimen of placebo drug is prescribed to the patient for 1 week after the first eye surgery
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Placeboplacebo drug pretreatment
Start Date: July 2014
Completed Date: February 2016
Phase: Phase 4
Primary Outcome: proportion of subjects who answer that "pain was greater" in the second eye surgery
Secondary Outcome: perioperative pain
Study sponsors, principal investigator, and references
Lead Sponsor: Seoul National University Hospital