Hordeolum | Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage
Hordeolum research study
What is the primary objective of this study?
To compare the effectiveness of combined antibiotic ophthalmic solution (neomycin sulfate, polymyxin B sulfate and gramicidin) with placebo (artificial tear) in the treatment of hordeolum after incision and curettage
Who is eligible to participate?
Inclusion Criteria: - at least 5-millimeters hordeolum - the onset within 7 days Exclusion Criteria: - previous incision and curettage of the same site within 1 month or more than 3 times - lesions in the adjacent areas suggesting of complications associated with hordeolum such as preseptal cellulitis or blepharitis - The patients with immunodeficiency, history of bleeding tendency - allergy to aminoglycoside, polymyxin B, gramicidin, xylocaine and povidone iodine
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:neomycin sulfate, polymyxin B sulfate and gramicidinto the effected eye 4 times a day
Drug:Artificial tear4 times daily
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
BArtificial tear containing antibiotic solution base
Acombined antibiotic ophthalmic solution (neomycin sulfate, polymyxin B sulfate and gramicidin)
Start Date: September 2007
Completed Date: December 2008
Phase: Phase 3
Primary Outcome: Pain scale
Secondary Outcome: Mass size and duration of cure
Study sponsors, principal investigator, and references
Principal Investigator: Parima Hirunwiwatkul, MD
Lead Sponsor: Chulalongkorn University
Hirunwiwatkul P, Wachirasereechai K. Effectiveness of combined antibiotic ophthalmic solution in the treatment of hordeolum after incision and curettage: a randomized, placebo-controlled trial: a pilot study. J Med Assoc Thai. 2005 May;88(5):647-50.