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Hordeolum | Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage

Hordeolum research study

What is the primary objective of this study?

To compare the effectiveness of combined antibiotic ophthalmic solution (neomycin sulfate, polymyxin B sulfate and gramicidin) with placebo (artificial tear) in the treatment of hordeolum after incision and curettage

Who is eligible to participate?

Inclusion Criteria: - at least 5-millimeters hordeolum - the onset within 7 days Exclusion Criteria: - previous incision and curettage of the same site within 1 month or more than 3 times - lesions in the adjacent areas suggesting of complications associated with hordeolum such as preseptal cellulitis or blepharitis - The patients with immunodeficiency, history of bleeding tendency - allergy to aminoglycoside, polymyxin B, gramicidin, xylocaine and povidone iodine

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Hordeolum

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:neomycin sulfate, polymyxin B sulfate and gramicidinto the effected eye 4 times a day

Drug:Artificial tear4 times daily

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

BArtificial tear containing antibiotic solution base

Acombined antibiotic ophthalmic solution (neomycin sulfate, polymyxin B sulfate and gramicidin)

Study Status

Unknown status

Start Date: September 2007

Completed Date: December 2008

Phase: Phase 3

Type: Interventional

Design:

Primary Outcome: Pain scale

Secondary Outcome: Mass size and duration of cure

Study sponsors, principal investigator, and references

Principal Investigator: Parima Hirunwiwatkul, MD

Lead Sponsor: Chulalongkorn University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT00534391

Hirunwiwatkul P, Wachirasereechai K. Effectiveness of combined antibiotic ophthalmic solution in the treatment of hordeolum after incision and curettage: a randomized, placebo-controlled trial: a pilot study. J Med Assoc Thai. 2005 May;88(5):647-50.

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