Primary Open Angle Glaucoma | Protective Effect of Phenytoin on Glaucoma
Primary Open Angle Glaucoma research study
What is the primary objective of this study?
since glaucoma is considered an optic neuropathy, new treatments for glaucoma are being continuously investigated, including neuroprotection. Previous studies implied that phenytoin, a potent anti-convulsive drug, has a neuroprotective role, and Na+ channels blockage was suggested as a possible mechanism. This study predicts that glaucoma patients taking Phenytoin will have a less advanced glaucoma as compared to patients not taking the drug. Glaucoma severity will be determined by visual acuity, visual fields, optic disc cupping and nerve fiber layer thickness
Who is eligible to participate?
Inclusion Criteria: - Clinical diagnosis of glaucoma - chronic treatment with phenytoin for any indication Exclusion Criteria: - pregnancy - visual acuity less then 6/60
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Primary Open Angle Glaucoma
Secondary Open Angle Glaucoma
Normal Tension Glaucoma
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
1glaucoma patients who also suffer from epileptic disorder and receiving chronic oral Phenytoin treatment
2glaucoma patients who also suffer from epileptic disorder receiving anti-convulsant treatment other then Phenytoin
3glaucoma patients with no epileptic disorder and not receiving anti-convulsant treatment
Start Date: November 2008
Completed Date: December 2010
Primary Outcome: peripapillary RNFL thickness
Secondary Outcome: corrected pattern standard deviation in perimetric visual field
Study sponsors, principal investigator, and references
Principal Investigator: Omer Y Bialer, MD
Lead Sponsor: Rabin Medical Center
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