Glaucoma | Myocilin Variations and Familial Glaucoma in Taxiarchis

Glaucoma research study

What is the primary objective of this study?

Taxiarchis, a small village in Northern Greece with 1060 inhabitants, was considered to have a surprisingly high incidence of glaucoma. This isolated population located on Mount Holomondas appeared to be enriched for familial glaucoma. Based upon the high reported incidence of glaucoma in Taxiarchis and previous findings of the Thr377Met myocilin mutation in the Greek population,the investigators undertook a community-based study to determine if this variant was present in this village.

Who is eligible to participate?

Inclusion Criteria: - Individuals born in Taxiarchis Exclusion Criteria: - Individuals that have not been born in Taxiarchis

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?


Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Villagers in Taxiarchis

Study Status

Active, not recruiting

Start Date: August 2007

Completed Date: January 2020


Type: Observational


Primary Outcome: Examining all of the villagers to determine the actual incidence of glaucoma in Taxiarchis and identify the Thr377Met myocilin mutation in glaucoma patients.

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Anastasios G Konstas, MD, PhD

Lead Sponsor: Aristotle University Of Thessaloniki


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