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Glaucoma | Corneal Endothelium After Glaucoma Surgery

Glaucoma research study

What is the primary objective of this study?

The purpose of this trial is to study the change in corneal endothelial cell after glaucoma surgery, non-contact specular microscopic examination is performed for the patients who underwent glaucoma surgery; trabeculectomy and Ahmed glaucoma valve implant surgery prospectively. Change in corneal endothelial cell density, hexagonality, and coefficient of variation of cell area will be analyzed and compared to the baseline and between the types of the surgeries.

Who is eligible to participate?

Inclusion Criteria: - Patients who need glaucoma surgery for intraocular pressure control Exclusion Criteria: - congenital glaucoma - Pre-existing corneal abnormality - lost from follow up without any ocular problem within 6 months from surgery

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Glaucoma

Corneal Damage

Intraocular Pressure

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

ControlEyes with glaucoma and on anti-glaucoma medication but without glaucoma surgery

Implant surgeryEyes underwent Ahmed glaucoma valve implantation

TrabeculectomyEyes underwent conventional trabeculectomy with mitomycin-C

Study Status

Completed

Start Date: August 2003

Completed Date: January 2009

Phase: N/A

Type: Observational

Design:

Primary Outcome: Change in corneal endothelial cell density, hexagonality, and coefficient of variation of cell area

Secondary Outcome: Clinical factors associated with the damage of corneal endothelium after glaucoma surgery

Study sponsors, principal investigator, and references

Principal Investigator: Young-ha Lee, MD, PhD

Lead Sponsor: Chungnam National University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT00863018

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