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Glaucoma | Earlier Intraocular Pressure Control After Ahmed Glaucoma Valve Implantation for Glaucoma

Glaucoma research study

What is the primary objective of this study?

The purpose of this study is to compare the occurrence rate of the high pressure phase and the final pressure outcomes between patients treated with glaucoma medication prior to the expected onset of the high pressure phase to those patients who have glaucoma medication started at the onset of the high pressure phase. The investigators hypothesize that if glaucoma medications are started prior to the expected onset of high pressure phase, the high pressure phase will not occur as frequently and the ultimate pressure level will be lower than if the glaucoma medications are started at the onset of this phase.

Who is eligible to participate?

Inclusion Criteria: 1. Patients requiring Ahmed glaucoma valve implantation to control intraocular pressure between the ages of 18 and 85 years. Exclusion Criteria: 1. Unwilling or unable to give consent or unwilling to accept randomization. 2. Patient out of area and potentially unavailable for follow-up visits. 3. Known allergic reaction to timolol, brimonidine, dorzolamide, brinzolamide, or sulfa drugs. 4. Known medical contraindications to the use of beta-blockers, including congestive heart failure, heart block, asthma, and chronic obstructive pulmonary disease. 5. Concurrent intraocular procedure with Ahmed glaucoma valve implantation 6. Previous Ahmed glaucoma valve implantation

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Glaucoma

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:glaucoma medications (Timolol, Brimonidine, Dorzolamide, Brinzolamide)Subjects may receive glaucoma medications after Ahmed valve implantation

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Research arm (postop IOP>10)Receive glaucoma medications if the eye pressure more than 10 mmHg after AHmed valve implantation

Standard of care arm (postop IOP>17)Receive glaucoma medication if eye pressure more than 17 mmHg after Ahmed valve implantation

Study Status

Completed

Start Date: March 2009

Completed Date: March 2013

Phase: Phase 4

Type: Interventional

Design:

Primary Outcome: Rate of Hypertensive Phase After Ahmed Valve Implantation for Glaucoma

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Simon K Law, MD

Lead Sponsor: University of California, Los Angeles

Collaborator:

More information:https://clinicaltrials.gov/show/NCT00869141

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