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Psychotic Disorders | Transcranial Direct Current Stimulation as Treatment for Auditory Hallucinations

Psychotic Disorders research study

What is the primary objective of this study?

The present study aims to examine the efficacy of transcranial direct current stimulation on the severity of auditory hallucinations.

Who is eligible to participate?

Inclusion Criteria: - Age over 18. - Frequent auditory hallucinations (at least 5 times a week). - Patients are on a stable dose of antipsychotic medication (which can also be zero) for at least 2 weeks - Mentally competent for informed consent. - Provided informed consent. Exclusion Criteria: - Metal objects in or around the head that cannot be removed (i.e. cochlear implant, surgical clips, piercing) - History of seizures, or a history of seizures in first-degree relatives. - History of eye trauma with a metal object or professional metal workers - History of brain surgery, brain infarction, head trauma, cerebrovascular accident, broken skull, brain tumour, heart disease, cardiac pacemaker. - Skin disease on the scalp on the position of the tDCS electrodes - Coercive treatment based on a judicial ruling - Pregnancy in female patients

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Psychotic Disorders

Mood Disorders

Personality Disorders

Stress Disorders, Post-Traumatic

Hearing Disorders

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Device:Eldith DC Stimulator stimulationThe anodal electrode will be placed with the middle of the electrode over a point midway between F3 and FP1 (left prefrontal cortex: dorsolateral prefrontal cortex and the cathodal electrode located over a point midway between T3 and P3 (left temporo-parietal junction). Stimulation will consist of 2 mA for 20 minutes per session.

Device:Eldith DC Stimulator sham stimulationThe anodal electrode will be placed with the middle of the electrode over a point midway between F3 and FP1 (left prefrontal cortex: dorsolateral prefrontal cortex and the cathodal electrode located over a point midway between T3 and P3 (left temporo-parietal junction). In the sham condition, after 40 seconds of real stimulation (2 mA), only a small current pulse will occur every 550 msec (110 mA over 15 msec) through the remainder of the 20-minute period.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Treatmenttranscranial direct current stimulation (2mA)

ShamSham stimulation

Study Status

Recruiting

Start Date: April 2014

Completed Date: February 2018

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Total score of the Auditory Hallucination Rating Scale (AHRS) questionnaire

Secondary Outcome: Changes in severity of hallucinations as assessed by the hallucination change scale (HCS)questionnaire

Study sponsors, principal investigator, and references

Principal Investigator: Iris Sommer, PhD

Lead Sponsor: Iris Sommer

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01977521

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