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Post-Traumatic Headache | Galantamine in the Treatment of Post-Traumatic Headache

Post-Traumatic Headache research study

What is the primary objective of this study?

Most patients with CPTH present with additional major cognitive, behavioral and somatic problems. Most drugs used currently have a negative influence on cognition. Therefore, treatment strategies addressing both the headache and cognitive disturbances in patients with CPTH are necessary. (CPTH; Chronic Post Traumatic Headache).

Who is eligible to participate?

Inclusion Criteria: Age range 18-75 CPTH according to ICHD-2 Fertile woman using adequate birth control Willing and able to give informed consent Willing and able to complete the entire course of the study to comply with study instructions Stable does of preventive medication - Exclusion Criteria: Subject is pregnant or lactating Significant medical or psychiatric disease Previous failure to 4 or more adequate trials of preventive medication Patient on non-stable dose of medication used to prevent CPTH -

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Post-Traumatic Headache

Head Trauma,Closed

Retention Disorders,Cognitive

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Galantamine

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Study Status

Unknown status

Start Date: July 2005

Completed Date: August 2005

Phase: Phase 4

Type: Interventional

Design:

Primary Outcome: Primary Headache Efficacy Measure; number of pain free days after 3 months

Secondary Outcome: Consumption of rescue medication

Study sponsors, principal investigator, and references

Principal Investigator: Alan Rapoport, MD

Lead Sponsor: Rapoport, Alan, M.D.

Collaborator: Ortho-McNeil Neurologics, Inc.

More information:https://clinicaltrials.gov/show/NCT00219869

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