Headache | Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

Headache research study

What is the primary objective of this study?

In this study the investigators will research the hypothesis that the gas carbon monoxide induces headache and increases the blood flow velocity in the middle cerebral artery.

Who is eligible to participate?

Inclusion Criteria: - Healthy volunteers - Aged 18-50 - 50-100 kg Exclusion Criteria: - Tension type headache more than once/month - Other primary headaches - Daily medication except contraceptives - Drug taken within 4 times the halflife for the specific drug except contraceptives - Pregnant or lactating women - Exposure to radiation within the last year - Headache within the last 24 hours before start of trial - Hypertension - Hypotension - Respiratory or cardiac disease - Smoking - Primary relatives with current or previous migraine

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?



Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:Carbon monoxidecarbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass.


Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

carbon monoxideInhalation of carbon monoxide up to a carboxyhemoglobin concentration of 12% and 22%.

placeboAtmospheric air

Study Status


Start Date: February 2014

Completed Date: December 2014

Phase: N/A

Type: Interventional


Primary Outcome: Headache scores

Secondary Outcome: Blood flow velocity

Study sponsors, principal investigator, and references

Principal Investigator: Nanna Arngrim, MD

Lead Sponsor: Danish Headache Center


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