Headache | Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
Headache research study
What is the primary objective of this study?
In this study the investigators will research the hypothesis that the gas carbon monoxide induces headache and increases the blood flow velocity in the middle cerebral artery.
Who is eligible to participate?
Inclusion Criteria: - Healthy volunteers - Aged 18-50 - 50-100 kg Exclusion Criteria: - Tension type headache more than once/month - Other primary headaches - Daily medication except contraceptives - Drug taken within 4 times the halflife for the specific drug except contraceptives - Pregnant or lactating women - Exposure to radiation within the last year - Headache within the last 24 hours before start of trial - Hypertension - Hypotension - Respiratory or cardiac disease - Smoking - Primary relatives with current or previous migraine
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Other:Carbon monoxidecarbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
carbon monoxideInhalation of carbon monoxide up to a carboxyhemoglobin concentration of 12% and 22%.
Start Date: February 2014
Completed Date: December 2014
Primary Outcome: Headache scores
Secondary Outcome: Blood flow velocity
Study sponsors, principal investigator, and references
Principal Investigator: Nanna Arngrim, MD
Lead Sponsor: Danish Headache Center