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Nut Allergy in Children | Tree Nuts Allergies: Does a Single Nut Allergy Necessitate the Dietary Eviction of Other Tree Nuts?

Nut Allergy in Children research study

What is the primary objective of this study?

The aim of this study is to identify, based on standardized food provocation tests, which nuts allergic patients need a selective, or a complete dietary eviction of all kind of nuts (nuts being defined as peanut, all tree nuts, pine nut and sesame). The investigators postulate that predictive factors of multiple nut allergy are high specific immunoglobulin E level, positive skin tests and/or clinical markers, such as atopic dermatitis, presence of other food allergies or a history of a severe previous reaction

Who is eligible to participate?

Inclusion Criteria: - Children 1 - 16 years of age at the time of inclusion (a minimum of 75 children < 6 years old required, over the 3 centers) - Children with convincing history of IgE-mediated systemic allergic reaction (not only oral symptoms) after consumption of one or more \"nuts\" (peanut, hazelnut, walnut, almond, cashew, pecan, Brazil, macadamia, pine nut, sesame) within last 12 months and SPT > 3 mm and/or positive specific IgE (>0.1 kU/l). - Children without a convincing history of IgE-mediated systemic allergic reaction (for example only oral symptoms) after consumption of one or more \"nuts\" (peanut, hazelnut, walnut, almond, cashew, pecan, brazil, macadamia, pistachio, pine nut, sesame) but with clear evidence of sensitization (SPT > 3 mm and/or positive specific IgE (> 0.1 kU/l) and a positive standardized food challenge to the nut. - Informed consent approved and signed by the patient's legal representative and, if applicable, by the child itself. Exclusion Criteria: - Uncontrolled asthma (according to the European Guidelines)(13) - Chronic urticaria - Children with a chronic systemic disease - Children who are dependent on daily antihistamine use

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Nut Allergy in Children

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:Oral food challenges to multiple nuts

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Interventional single armSingle group of children undergoing the same investigations and follow up

Study Status

Completed

Start Date: October 2012

Completed Date: September 2018

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Evaluation of cross reactivity in nut allergic children

Secondary Outcome: Identify predictive factors of multiple nut allergy

Study sponsors, principal investigator, and references

Principal Investigator: Philippe A Eigenmann, MD

Lead Sponsor: University Hospital, Geneva

Collaborator: Allergistiftung Ulrich Müller

More information:https://clinicaltrials.gov/show/NCT01744990

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