Food Allergy | Molecular Basis of Food Allergy
Food Allergy research study
What is the primary objective of this study?
The Study examines the molecular basis of food allergy. It explores the interaction between T cells, InKT cells and cytokines in the development of food allergy. The study also explores these factors in development of tolerance \"outgrowing\" food allergy. It will also explore the genetic factors that lead to the development of food allergy. The study examines all type of food allergy including IgE mediated reactions, Eosinophilic Esophagitis and Food Protein Induced Enterocolitis
Who is eligible to participate?
Inclusion Criteria for Study Group: 1. Males or females age 1 month to 65 years. 2. Diagnosis of Food Allergy. Food Allergy can be either IgE or non-IgE mediated food allergy including Eosinophilic Esophagitis and Food Protein Induced Enterocolitis. Inclusion Criteria for Control group: 1. Age and sex matched patients without food allergies 2. Sibling and parents of patients with food allergies Inclusion Criteria for Control group with atopy: 1. Age and sex matched patients without food allergies 2. Sibling and parents of patients with food allergies 3. Patients with atopy Exclusion Criteria 1. Underlying disease or medical problem that is judged to serious or risky to allow 3 ml/kg of blood to be drawn from a vein (such as serious anemia, cancer, poor vein abscess, serious infections). 2. Subjects that do not meet the enrollment criteria may not be enrolled. Any violations of these criteria will be reported in accordance with IRB policies and procedures study procedures.
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Start Date: January 2011
Completed Date: December 2019
Primary Outcome: T cell Phenotype in Patients with Food Allergy
Study sponsors, principal investigator, and references
Principal Investigator: Jonathan M Spergel, MD, PhD
Lead Sponsor: Children's Hospital of Philadelphia
Collaborator: University of Pennsylvania