Hypertension | Simvastatin in Patients With Isolated Arterial Hypertension
Hypertension research study
What is the primary objective of this study?
The purpose of this study is to determine whether combined therapy with simvastatin and hypotensive drugs (ACEI or ARB) may decrease the blood pressure. Moreover, we would like to assess the influence of isolated hypertension on endothelial injury, and on the development of atherosclerosis.
Who is eligible to participate?
Inclusion Criteria: - isolated hypertension (I or II class according to ESH guidelines 2009) Exclusion Criteria: - ischemic heart disease, prior percutaneous coronary intervention (PCI), prior coronary artery bypass grafting (CABG), heart failure, diabetes, hyperlipidemia, active smokers
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
statin treatment, isolated hypertensiontreatment with statins, patients with isolated hypertension, with no hyperlipidemia, no diabetes, no smoking
placebo treatment, isolated hypertensiontreatment with placebo, patients with isolated hypertension, with no hyperlipidemia, no diabetes, no smoking
Start Date: November 2009
Completed Date: January 2012
Study sponsors, principal investigator, and references
Principal Investigator: Maciej Banach, MD PhD
Lead Sponsor: Medical Universtity of Lodz
Stepien M, Banach M, Mikhailidis DP, Gluba A, Kjeldsen SE, Rysz J. Role and significance of statins in the treatment of hypertensive patients. Curr Med Res Opin. 2009 Aug;25(8):1995-2005. doi: 10.1185/03007990903098081. Review.