Myeloproliferative Disease | A Case Control Study of the Prevalence of Pulmonary Hypertension in Patients With Myeloproliferative Diseases.

Myeloproliferative Disease research study

What is the primary objective of this study?

Pulmonary hypertension (PH) is defined as a group of diseases characterised by an elevated mean pulmonary artery pressure (Ppa) ≥25 mmHg at rest. Recently, chronic myeloproliferative diseases (CMPD) associated with pulmonary hypertension were included in the group 5 category, corresponding to PH for which the aetiology is unclear and/or multifactorial. CMPD include chronic myelogenous leukaemia, chronic neutrophilic leukaemia and chronic eosinophilic leukaemia (which primarily express a myeloid phenotype and polycythaemia vera), idiopathic myelofibrosis, and essential thrombocytosis in which erythroid or megakaryocytic hyperplasia predominates. The purpose of this research: 1. Assess Prevalence of PH in patients with CMPD in Northern Israel 2. Describe the demographics and clinical course in patients with CMPD who are diagnosed with PH.

Who is eligible to participate?

Inclusion Criteria: 1) consenting patients diagnosed with a myeloproliferative disease Exclusion Criteria: 1) Refusal to have an echocardiogram or answer the St. George respiratory questionnaire

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Myeloproliferative Disease

Pulmonary Hypertension

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:myeloproliferative diseaseEchocardiogram, demographic data, St George respiratory questioner

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

myeloproliferative diseasePatients with Myeloproliferative Diseases as specified under inclusion and exclusion criteria

Study Status

Unknown status

Start Date: July 2013

Completed Date:

Phase: N/A

Type: Observational


Primary Outcome: pulmonary hypertension

Secondary Outcome: St George Respiratory Questionnaire

Study sponsors, principal investigator, and references

Principal Investigator: Shoshan Perek, MD

Lead Sponsor: Carmel Medical Center


More information:

Discuss Hypertension