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Acute Lung Injury | Timing and Intensity of the Exposures and Attributable Burden of Acute Lung Injury

Acute Lung Injury research study

What is the primary objective of this study?

The purpose of the study is to identify the patients at high risk of developing Acute Lung Injury (ALI) at the time of hospital admission, and before intensive care unit admission. Aim 1- To validate the prediction model (Lung Injury Prediction Score) in a population based sample of hospitalized patients. Aim 2- To determine the significance of health-care related ALI risk modifiers in a population based sample. Aim 3- To compare the short and long term outcomes between patients at high risk who do, and do not develop ALI.

Who is eligible to participate?

Inclusion Criteria: - All Olmsted County residents more than 18 years of age who were admitted to the two Mayo Clinic Rochester hospitals Exclusion Criteria: - Denied the use of medical records for research - Acute lung injury or pulmonary edema already present at the time of hospital admission - Admitted for comfort or hospice care only - Children - Hospital readmission - Patients admitted for cardiac telemetry, coronary care unit, low risk elective surgeries, labor and delivery

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Acute Lung Injury

Acute Respiratory Distress Syndrome

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

At risk for Acute Lung InjuryControls-High risk patients at risk of Acute Lung Injury(ALI) but do not develop ALI Cases-High risk patients that do develop Acute Lung Injury

Study Status

Recruiting

Start Date: December 2008

Completed Date: December 2017

Phase: N/A

Type: Observational

Design:

Primary Outcome: Development of ALI

Secondary Outcome: Quality adjusted survival

Study sponsors, principal investigator, and references

Principal Investigator: Ognjen Gajic, M.D.

Lead Sponsor: Mayo Clinic

Collaborator:

More information:https://clinicaltrials.gov/show/NCT00980915

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