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Autism | Cognitive-Behavioral Therapy for Irritability in Adolescents With High Functioning Autism Spectrum Disorder

Autism research study

What is the primary objective of this study?

In addition to the core symptoms, children and adolescents with Autism Spectrum Disorder (ASD) often exhibit disruptive behavior problems including irritability, tantrums, noncompliance, and aggression. This is a pilot study of Cognitive-Behavioral Therapy, also known as Anger Control Training, in adolescents with high-functioning ASD. CBT teaches children to recognize antecedents and consequences of problem behavior and to use emotion regulation and problem-solving skills to reduce irritability, aggression and noncompliance. This form of CBT has been well-studied in typically developing children with disruptive behavior and we are investigating if this treatment can be feasible and helpful, with appropriate modifications, for irritability and disruptive behavior in ASD.

Who is eligible to participate?

Inclusion Criteria: - DSM-IV diagnosis of autistic disorder, Asperger's disorder, or PDD-NOS - presence of disruptive behaviors such as irritability and anger outbursts - IQ above 80 - Unmedicated or on stable medication Exclusion Criteria: - medical or psychiatric condition that would require alternative treatment

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Autism

Autism Spectrum Disorder (ASD

Asperger's Disorder

Pervasive Developmental Disorder (PDD-NOS)

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Behavioral:Cognitive-Behavioral Therapy (CBT) for IrritabilityCBT is an individually administered behavioral interventions aimed at reducing irritability and disruptive behavior. There are 10 to 12 weekly sessions that are conducted with the child and the parent. During these sessions children are taught to recognize antecedents and consequences of problem behavior and to use emotion regulation and problem-solving skills to reduce irritability, aggression and noncompliance.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Cognitive behavior therapy

Study Status

Active, not recruiting

Start Date: May 2011

Completed Date: December 2018

Phase: N/A

Type: Interventional

Design:

Primary Outcome: ABC Irritability Scale

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Denis Sukhodolsky, Ph.D.

Lead Sponsor: Yale University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01631851

Sukhodolsky DG, Vitulano LA, Carroll DH, McGuire J, Leckman JF, Scahill L. Randomized trial of anger control training for adolescents with Tourette's syndrome and disruptive behavior. J Am Acad Child Adolesc Psychiatry. 2009 Apr;48(4):413-21. doi: 10.1097/CHI.0b013e3181985050.

Discuss Irritability