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Irritable Bowel Syndrome | Assessment of Small Intestinal Bowel Epithelial Gaps in Irritable Bowel Syndrome

Irritable Bowel Syndrome research study

What is the primary objective of this study?

The study aims to: 1. Determine whether the density of epithelial gaps in terminal ileum of patients with irritable bowel syndrome (IBS) is different from that in inflammatory bowel disease (IBD) patients and normal controls by confocal laser endomicroscopy (CLE). 2. Evaluate the relationship between the density of epithelial gaps and IBS subtypes, and visceral hypersensitivity.

Who is eligible to participate?

Inclusion Criteria: - Bowel habits alterations meeting IBS Rome III criteria and indications for colonoscopy investigation - Patients with history of inflammatory bowel disease - Asymptomatic individuals for health surveillance or patients for follow up after polypectomy - Patients complained of hemafecia but colonoscopy revealed only haemorrhoid Exclusion Criteria: - Patients with known cancers or abdominal surgery - Alarm symptoms such as anaemia, gastrointestinal bleeding or obstruction, marked weight loss, abdominal mass - Patients who are unwilling to sign or give the informed consent form - Patients who are allergic to fluorescein sodium - Patients with impaired cardiac, liver or renal function - Patients with coagulopathy - Patients with pregnancy or breastfeeding

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Irritable Bowel Syndrome

Inflammatory Bowel Disease

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Irritable bowel syndromePatients admitted to outpatient department with symptoms meeting Rome III criteria of irritable bowel syndrome.

InflammationPatients with long standing history or short onset of inflammatory bowel disease.

Normal controlsAsymptomatic individuals admitted for health surveillance or patients for follow up after polypectomy.

Study Status

Unknown status

Start Date: June 2012

Completed Date: December 2012

Phase:

Type: Observational

Design:

Primary Outcome:

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Yanqing Li, MD, PhD

Lead Sponsor: Shandong University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01632488

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