Hypertension | Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study

Hypertension research study

What is the primary objective of this study?

The purpose of this study is to develop an approach to provide personalized medicine to individuals who have hypertension (high blood pressure). The investigators plan to use people's genetic characteristics (traits) to determine what medication they should use to lower their blood pressure most effectively. The investigators will give individuals one of two medications to treat hypertension (lisinopril or atenolol). The investigators believe that depending on the individuals genetic background one medication will work better in lowering their blood pressure.

Who is eligible to participate?

Inclusion Criteria: - Male and female hypertensive participants who were previously studied in SCOR program. Exclusion Criteria: - Diabetes - Taking other medications beside thyroid or estrogen supplements.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?


Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Lisinopril, Atenololonce a day for 14 weeks

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Lisinopril, Atenolol

Study Status

Active, not recruiting

Start Date: January 2007

Completed Date: March 2018

Phase: N/A

Type: Interventional


Primary Outcome: One type of blood pressure medication will better treat individuals with certain genetic backgrounds.

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Gordon H. Williams, MD

Lead Sponsor: Brigham and Women's Hospital

Collaborator: University of Utah

More information:

Discuss Lisinopril