Hypertension | Bedtime Administration of Amlodipine Versus Lisinopril
Hypertension research study
What is the primary objective of this study?
This study seeks to compare the differences in effectiveness among individual patients treated at for hypertension with bedtime administration of amlodipine versus lisinopril. There will be an analysis of whether one medication was more effective than another and whether specific patient factors could predict who responded better to which one.
Who is eligible to participate?
Inclusion Criteria: - Age 40 to 80 - Newly diagnosed hypertension based on 24 hour ambulatory blood pressure monitor criteria. - Minimum Asleep SBP mean of ≥ 120mmHg for inclusion. Exclusion Criteria: - Current antihypertensive medication use - Baseline GFR < 45 - Preexisting macroproteinuria - Chronic congestive heart failure - History of CVA - Diabetes Mellitus - Pregnancy - Night-shift work - Other preexisting contraindication to amlodipine or lisinopril
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:Amlodipinecrossover comparison of amlodipine vs lisinopril
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Lisinoprilbedtime administration of lisinopril 20mg
AmlodipineBedtime administration of amlodipine 5mg
Start Date: April 2013
Primary Outcome: Change in mean sleep-time systolic blood pressure after addition of a bedtime dose of amlodipine versus lisinopril
Secondary Outcome: Changes in mean sleep-time diastolic, awake systolic and diastolic blood pressures, including comparison of % achieving target BP
Study sponsors, principal investigator, and references
Lead Sponsor: Allina Health System