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Liver Cirrhosis | Fatty Acids Lipidome and Oxidative Stress in Liver Transplantation

Liver Cirrhosis research study

What is the primary objective of this study?

The purpose of this study is to determine lipid metabolism in chronic liver disease in the attempt to find a useful biomarker of liver function and of prognostic value of graft function in those patients who undergo liver transplant. The present study enrolls subjects with liver cirrhosis (with different ethiology), including subjects eligible for a full-size liver transplantation, and healthy controls.

Who is eligible to participate?

Liver cirrhosis inclusion criteria: - subjects with liver cirrhosis eligible for liver transplant, and one MELD score determination performed at least 3 months before liver transplantation Liver cirrhosis exclusion criteria: - liver transplant contraindication and re-transplantation - current use of antioxidants and fatty acids supplements Healthy controls are recruited recruited among the University personnel, after a review of their medical history. Exclusion criteria for control participants included the use of drugs that affect fatty acids (systemic corticosteroids, isotretinoin, and ursodiol) and/or oxidative stress (antioxidants and hypolipemic drugs).

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Liver Cirrhosis

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Liver CirrhosisPatient with liver cirrhosis undergoing liver transplant

Liver donorsSubjects eligible for organ explant

Healthy controls

Study Status

Unknown status

Start Date: July 2001

Completed Date: September 2016

Phase:

Type: Observational

Design:

Primary Outcome: Post operative graft function after liver transplantation

Secondary Outcome: Early gene expression in the liver graft

Study sponsors, principal investigator, and references

Principal Investigator: Stefano Corradini, M.D., Ph.D.

Lead Sponsor: University of Roma La Sapienza

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01389115

Poli G. Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med. 2000 Jun;21(3):49-98. Review.

Corradini SG, Micheletta F, Natoli S, Iappelli M, Di Angelantonio E, De Marco R, Elisei W, Siciliano M, Rossi M, Berloco P, Attili AF, Diczfalusy U, Iuliano L. High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. Liver Transpl. 2005 Dec;11(12):1494-504.

Iuliano L, Micheletta F, Natoli S, Ginanni Corradini S, Iappelli M, Elisei W, Giovannelli L, Violi F, Diczfalusy U. Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status. Anal Biochem. 2003 Jan 15;312(2):217-23.

Corradini SG, Elisei W, De Marco R, Siciliano M, Iappelli M, Pugliese F, Ruberto F, Nudo F, Pretagostini R, Bussotti A, Mennini G, Eramo A, Liguori F, Merli M, Attili AF, Muda AO, Natalizi S, Berloco P, Rossi M. Preharvest donor hyperoxia predicts good early graft function and longer graft survival after liver transplantation. Liver Transpl. 2005 Feb;11(2):140-51.

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