Coronary Artery Disease | Comparison of Efficacy of Ivabradine Versus Metoprolol

Coronary Artery Disease research study

What is the primary objective of this study?

Ivabradine may be better than Metoprolol for controlling heart rate before Coronary CTA.

Who is eligible to participate?

Inclusion Criteria: - elective patient on scheduled for 640 slices CT coronary at Phramonkutklao hospital - Resting heart rate > 70 BPM - age > 18 years and informed consent Exclusion Criteria: - Heart rate > 100 BPM - BP <100/60 mmHg - recent congestive heart failure in 1 mo. - SA node, AV node disease and AF - on permanent pacemaker - CrCL < 15ml/min. , AST or ALT > 3x UNL - on HR reducing drug such as diltiazem, verapamil, digitalis - contraindication for ivabradine or metoprolol

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Coronary Artery Disease

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Ivabradine and Metoprolol

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

IvabradinePatients will recieved ivabradine(5) 1 tab bid pc for 3 day and the day of CT, and recieve placebo of metoprolol

metoprololMetoprolol (100) 1/2 tab bid pc for 3 day and the day of CT coronary , and placebo of ivabradine

Study Status

Unknown status

Start Date: December 2014

Completed Date: December 2015

Phase: Phase 4

Type: Interventional


Primary Outcome: Heart rate of patient before CT coronary

Secondary Outcome: safety and side effect of Metoprolol and Ivabradine

Study sponsors, principal investigator, and references

Principal Investigator: Purich - Surunchupakorn, M.D.

Lead Sponsor: Col. Suthee Panichkul

Collaborator: Phramongkutklao College of Medicine and Hospital

More information:

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