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Inguinal Hernia | Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain

Inguinal Hernia research study

What is the primary objective of this study?

The study carry out is to determine whether the use of oral pregabalin premedication to assess the analgesic efficacy, opiod sparing, adverse effect and clinical value in post-operative pain management.

Who is eligible to participate?

Inclusion Criteria: - Clinical diagnosis of inguinal hernia - Patient undergo operation under daycare basis - ASA I-II - Written consent Exclusion Criteria: - ASA > II - Allergic reaction against gabapentin and/or pregabalin - History of recurrent hernia repair. - Patient who has taken analgesia prior to the surgery - Liver failure - Renal failure - Pregnancy

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Inguinal Hernia

Postoperative Pain

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:PregabalinThe patient under Group P will be serving with 150 mg of oral Pregabalin 1 to 2 hours prior to induction.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Pregabalin GroupThe patient under Group P will be serving with 150 mg of oral Pregabalin 1 to 2 hours prior to induction.

Study Status

Unknown status

Start Date: September 2009

Completed Date: December 2011

Phase: Phase 3

Type: Interventional

Design:

Primary Outcome: Study is constructed to determine whether the use of oral pregabalin premedication to assess the analgesic efficacy for post operative pain at Alert, 15, 30, 45, 60 and 120 min, Day 1, Day 2 and Day 3.

Secondary Outcome: Opiod Sparing

Study sponsors, principal investigator, and references

Principal Investigator: CharngChee Toh, MBBS, MRCS

Lead Sponsor: University of Malaya

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01450345

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