Postoperative Pain | The Effects of Pregabalin on Postoperative Pain After Cardiac Surgery
Postoperative Pain research study
What is the primary objective of this study?
The purpose of this study is to determine whether pregabalin is effective in the treatment of acute postoperative pain after cardiac surgery if administered before the surgery.
Who is eligible to participate?
Inclusion Criteria: - Patients' age 18-85years who are undergoing cardiac surgery Exclusion Criteria: - Chronic pain syndromes - Renal failure - Age >85 - Allergy to Pregabalin - Patients already taking pregabalin
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:Pregabalin 75mgPregabalin 75mg by mouth one hour before surgery
Drug:pregabalin 150 mgpregabalin 150mg by mouth one hour before surgery
Drug:PlaceboSugar pill designed to mimic pregabalin capsule, by mouth one hour before surgery
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Pregabalin 75Pregabalin 75mg by mouth one hour before surgery
Pregabalin 150Pregabalin 150mg by mouth one hour before surgery
Sugar pillPlacebo : Sugar pill manufactured to mimic pregabalin capsule by mouth one hour before surgery
Start Date: July 2011
Completed Date: June 2016
Phase: Phase 2/Phase 3
Primary Outcome: opioid consumption and other analgesics after surgery
Secondary Outcome: Remaining surgery related pain and analgesics consumption
Study sponsors, principal investigator, and references
Principal Investigator: Aikaterini A Bouzia, Medicine
Lead Sponsor: Larissa University Hospital