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Critically Ill | 2012_PharmacoCRRT-study:Pharmacokinetics of Anti-infectives in Critically Ill Patients in Need of Continuous Renal Replacement Therapy (CRRT)

Critically Ill research study

What is the primary objective of this study?

The main purpose of the study is to examine if changes in pharmacokinetics of important antiinfectives in Critically Ill patients in need of continuous renal replacement therapy (CRRT), causes inadequate concentrations in plasma. The effect of different modus of CRRT: CVVH and CVVHD will be compared, as well as type of filter, filter lifetime etc. Hypothesis: The risk of incorrect dosage of antiinfectives - to low/ to high- is increased in critically ill patients receiving CRRT. Inadequate plasma concentrations of antiinfectives may contribute to increased mortality in this group.

Who is eligible to participate?

Inclusion Criteria: 1. Patients admitted to ICU in need of antiinfectives: 1. in need of CRRT 2. without acute kidney failure 2. requirement for antiinfectives> 72 hrs 3. Age > 18 yrs 4. signed informed consent Exclusion Criteria: 1. Acute or chronic renal failure not in need of CRRT 2. Age < 18 yrs

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Critically Ill

Acute Renal Failure

Acute Kidney Injury

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

antiinfectiva: vancomycin80 patients Completed.

antiinfectiva: meropenem80 patients recruiting

antiinfectiva: flukonazol80 patients

antiinfectiva: cefotaxim80 patients

antiinfectiva: benzylpenicilline80 patients

antiinfectiva: tazobactam piperacillin80 patients recruiting

antiinfectiva: cloxacillin80 patients

antiinfectiva: ciprofloxacin80 patients

Study Status

Unknown status

Start Date: May 2013

Completed Date: January 2018

Phase:

Type: Observational

Design:

Primary Outcome: Sub-therapeutic levels of measured antiinfectiva

Secondary Outcome: SOFA-score

Study sponsors, principal investigator, and references

Principal Investigator: Elin Helset, MD PhD

Lead Sponsor: Oslo University Hospital

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01582360

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