Critically Ill Patients | Observational Prospective Study of the Predicted Value of Immature Thrombocytes Counts in Three Different Groups of Critically Ill Patients

Critically Ill Patients research study

What is the primary objective of this study?

Immature Platelet Fraction (IPF) is a new value in CBC blood tests Recent Studies showed that this value may be another prognostic factor in critically ill patients such as those admitted to ICU, or those with neutropenic Fever. The purpose of the study is to check if the IPF may be used as a prognostic Factor in these patients

Who is eligible to participate?

Inclusion Criteria: - Admission to hospital blood sample is taken between 24:00 pm till 15:00 pm Exclusion Criteria: - blood sample is taken after 15:00 pm in the first day of admission during the week - blood sample is taken on weekend: thursday 15:00 pm till saturday 24:00 pm

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Critically Ill Patients

Neutropenic Fever Patients

Patients With Hip Fractures

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Other:Immature Platelet Fraction

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Critically ill patients admitted to ICUthose patients who are admitted to ICU with multiorgan failure/injury

Neutropinc Fever patientsadmitted to ER, haemato-oncology or oncology

Patients of Hip's Fractureadmitted to orthopedic departement

Study Status

Unknown status

Start Date: January 2014

Completed Date: November 2014


Type: Observational [Patient Registry]


Primary Outcome: Time to recovery from sepsis or time to death

Secondary Outcome: Predicting value of IPF for prognosis

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: Dr. Yishai Ofran


More information:

Di Mario A, Garzia M, Leone F, Arcangeli A, Pagano L, Zini G. Immature platelet fraction (IPF) in hospitalized patients with neutrophilia and suspected bacterial infection. J Infect. 2009 Sep;59(3):201-6. doi: 10.1016/j.jinf.2009.07.007. Epub 2009 Jul 18.

De Blasi RA, Cardelli P, Costante A, Sandri M, Mercieri M, Arcioni R. Immature platelet fraction in predicting sepsis in critically ill patients. Intensive Care Med. 2013 Apr;39(4):636-43. doi: 10.1007/s00134-012-2725-7. Epub 2012 Oct 24.

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