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Pain, Postoperative | Efficacy Methadone for Management Postoperative Pain After the Use of Anesthesia Intravenous in Laparoscopic Cholecystectomy

Pain, Postoperative research study

What is the primary objective of this study?

The aim of this study is to compare the efficacy of methadone versus morphine in dealing with postoperative pain, in laparoscopic cholecystectomy under total intravenous anesthesia (TIVA); Efficacy is defined in terms of the difference of milligrams in morphine used as rescue analgesia postoperatively. Our hypothesis is that methadone is more effective than morphine for postoperative pain treatment.

Who is eligible to participate?

Inclusion Criteria: - Patients undergoing laparoscopic cholecystectomy in the Almirante Nef Naval Hospital - Patients ASA 1 or 2 Exclusion Criteria: - Patients with renal insufficiency (creatinine> 2.0 mg / dl) - Patients with a history of liver failure - Patients with BMI> 35 kg/m2 - Patients with hypersensitivity to the drugs in question - History of chronic use of opioids - Need for conversion to open surgery

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Pain, Postoperative

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:MorphineMorphine group,receive morphine 0.08 mg / kg at the start of surgery

Drug:MethadoneMethadone group,receive methadone 0.08 mg / kg at the start of surgery

Drug:TIVATIVA: General anesthesia will be based on Remifentanil and Propofol (TIVA-TCI), titrated to achieve bispectral index (BIS) between 40 and 60.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Morphinemorphine group 0.08 mg / kg, to start surgery

Methadonemethadone group 0.08 mg / kg, to start surgery

Study Status

Completed

Start Date: March 2013

Completed Date: September 2013

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Difference in milligrams of morphine used as rescue analgesia

Secondary Outcome: Difference in pain scores, using the Numeric Rating Scale

Study sponsors, principal investigator, and references

Principal Investigator: NICOLAS ARRIAZA, Physician

Lead Sponsor: Universidad de Valparaiso

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01833715

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