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Migraine With and Without Aura | Migraine and Body Composition

Migraine With and Without Aura research study

What is the primary objective of this study?

This research is being done to look at the association between migraine and obesity.

Who is eligible to participate?

Inclusion Criteria: - Premenopausal women (18-55 years) - Normal weight (BMI = 18.5 - 24.9) or obese (BMI ≥ 30) - Diagnosis of episodic or chronic migraine or pain free control Exclusion Criteria: - Evidence of pain disorder other than migraine (e.g. irritable bowel syndrome) - Chronic conditions known to alter risk or pattern of migraine (e.g. hypothyroidism) - Illnesses that may affect adipokine levels (e.g. diabetes) - Clinically relevant abnormal glucose/cholesterol levels - Pregnant women - Potential participants who are unable to undergo MRI based on standard screening questionnaire (those with brain aneurysm or surgical clips, certain types of artificial heart valves, heart defibrillator or pacemaker, cochlear implants, eye implants, blood vessel coil, recently placed artificial joints, certain types of vascular stents, history of bullets, pellets, BBs, history of any implanted metal or device or who have worked with sheet metal in the past)

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Migraine With and Without Aura

Chronic Migraine

Healthy Controls

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Episodic migraineursThose with migraines >2 and < 12 times per month.

Chronic migraineursThose with migraines greater than 14 days per month.

ControlsThose without headaches other than occasional hangover, cold, flu headaches.

Study Status

Completed

Start Date: April 2012

Completed Date: October 2015

Phase: N/A

Type: Observational

Design:

Primary Outcome: association between migraine and obesity - evaluate serum adipokine levels

Secondary Outcome: association between migraine and obesity -evaluate subcutaneous adipose tissue (SAT) and its ratio to visceral adipose tissue (VAT)

Study sponsors, principal investigator, and references

Principal Investigator: Barbara L Peterlin, DO

Lead Sponsor: Johns Hopkins University

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01720862

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