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Migraine Without Aura | PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load

Migraine Without Aura research study

What is the primary objective of this study?

The investigators hypothesized that migraine without patients with many genetic loci associated with migraine (high genetic load) would be more sensitive and get provoked more migraine attacks by PACAP compared to patients with few genetic loci associated with migraine (low genetic load).

Who is eligible to participate?

Inclusion Criteria: - Migraine without aura patients genotyped for the 12 newly idetified gene variants associated with migraine. Exclusion Criteria: - Other primary headache - A history of cerebrovascular disease and other CNS- disease - A history suggesting ischaemic heart disease - Serious somatic and mental disease - Hypo- or hypertension - Abuse of alcohol or medicine (opioid analgesics). - Pregnant or breastfeeding women.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Migraine Without Aura

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:PACAPPituitary adenylate cyclase-activating polypeptide (PACAP)

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Migraine patients with high genetic loadPACAP intravenous infusion 1.5 microgram/min for 20 min

Migraine patients with low genetic loadPACAP intravenous infusion 1.5 microgram/min for 20 min

Study Status

Completed

Start Date: June 2014

Completed Date: December 2014

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Incidence of migraine attacks induced by PACAP in patients with high and low genetic load.

Secondary Outcome: Incidence of headache induced by PACAP in patients with high and low genetic load.

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: Danish Headache Center

Collaborator:

More information:https://clinicaltrials.gov/show/NCT02158221

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