Postoperative Pain | Postoperative Analgesia in Children After Propofol Anesthesia
Postoperative Pain research study
What is the primary objective of this study?
The investigators hypothesize that patients anesthetized with sevoflurane have more pain, postoperatively, than those anesthetized with propofol.
Who is eligible to participate?
Inclusion Criteria: - Patient is 3- 6 years old - Patient is scheduled for hernia repair surgery at University Clinical center of Kosovo Patients is ASA I/II Patient meets criteria to receive either propofol or sevoflurane anesthesia Patient's parent/guardian provides written consent Exclusion Criteria: - allergy to any of the drugs - preoperative anxiety - postoperative agitation - ASA physical status >II
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Drug:PropofolThe induction dose of propofol is 3-5 mg/kg-1 (mean induction dose: 4 mg/kg-1) follow by propofol infusion (12 mg/kg/h-1 for the first 10 min of general anesthesia, 9 mg/kg/h-1 for another 10 min, and 6 mg/kg/h-1 thereafter; mean maintenance dose: 9 mg/kg/h-1) and a 50:50 mixture of N2O and O2.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
drug: propofolDrug:Propofol and sevoflurane The induction dose of propofol is 3-5 mg/kg-1 (mean induction dose: 4 mg/kg-1) follow by propofol infusion (12 mg/kg/h-1 for the first 10 min of general anesthesia, 9 mg/kg/h-1 for another 10 min, and 6 mg/kg/h-1 thereafter; mean maintenance dose: 9 mg/kg/h-1) and a 50:50 mixture of N2O and O2.
Sevoflurane group:sevofluraneDrug:Sevoflurane and Propofol Mask induction is perform with sevoflurane (4-6%) follow by 1.5-2% sevoflurane in a 50:50 mixture of N2O and O2.
Start Date: September 2010
Completed Date: July 2011
Phase: Phase 1/Phase 2
Primary Outcome: postoperative pain
Secondary Outcome: recovery time
Study sponsors, principal investigator, and references
Principal Investigator: Antigona Hasani, MD,MSC
Lead Sponsor: University Clinical Centre of Kosova