Muscle Damage | Effect of American Ginseng on Exercise-induced Muscle Soreness

Muscle Damage research study

What is the primary objective of this study?

Healthy participants will ingest American ginseng daily or a placebo for four weeks prior to engaging in a unaccustomed exercise bout designed to induce mild-moderate muscle soreness. Muscle soreness will be assessed via decrements in muscle strength and with a self-rating of perceived soreness before and several times after the exercise.

Who is eligible to participate?

Inclusion Criteria: - Healthy men or women, (women must weigh between 55-65 kg., while men must weigh between 75-85kg). - Participants must not have engaged in any endurance run training in the past 9 months. Exclusion Criteria: - Injured - Regular runners - Pregnant (or with any chance they may become pregnant) - Breast-feeding - Diabetics or those taking medication for diabetes - Insomniacs - Schizophrenics - Hyper- or hypotension - Cancer - Irregular heartbeats - Heart disease - Females with endometriosis or uterine fibroids - Those who have surgery scheduled during the study or within the two weeks following the completion of the study - Those taking warfarin or medication for depression.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Muscle Damage

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Dietary Supplement:GinsengEffect of four weeks of daily Ginseng intake (2gm/day) on muscle soreness following downhill running exercise

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

TreatmentAmerican Ginseng ingestion

Placeobonon-active ingredient

Study Status


Start Date: May 2013

Completed Date: December 2013

Phase: Phase 1

Type: Interventional


Primary Outcome: muscle strength

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Peter WR Lemon, PhD

Lead Sponsor: Lawson Health Research Institute


More information:

Jung HL, Kwak HE, Kim SS, Kim YC, Lee CD, Byurn HK, Kang HY. Effects of Panax ginseng supplementation on muscle damage and inflammation after uphill treadmill running in humans. Am J Chin Med. 2011;39(3):441-50.

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