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Intubating Conditions | Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy

Intubating Conditions research study

What is the primary objective of this study?

Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A alternative is the application of low dose mivacurium, reversed with neostigmine. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM), patient satisfaction and the postoperative performance with respiration exercise device for these two muscle relaxants.

Who is eligible to participate?

Inclusion Criteria: - age > 18 yr - scheduled for elective rigid bronchoscopy Exclusion Criteria: - known neuromuscular disease - significant hepatic or renal dysfunction - family history of malignant hyperthermia - known allergy to one of the drugs used in this protocol - pregnancy or breastfeeding

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Intubating Conditions

Performance With Respiratory Exercise Device

Postoperative Myalgia

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:SuccinylcholineAnaesthesia was induced and maintained with propofol(1-2mg/kg and 5mg/kg/h) and remifentanil (1µg/kg and 0,2µ/kg/min). The study arm is immobilized and a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. the patients receive the muscle relaxant according to the study group.

Drug:MivacuriumAnaesthesia was induced and maintained with propofol(1-2mg/kg and 5mg/kg/h) and remifentanil (1µg/kg and 0,2µ/kg/min). The study arm is immobilized and a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. the patients receive the muscle relaxant according to the study group.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

SuccinylcholinePatient receive succinylcholine as a muscle relaxant (0,5mg/kg) after induction of general anaesthesia for rigid bronchoscopy.

MivacuriumPatients receive mivacurium (0,08mg/kg) as a muscle relaxant after induction of general anaesthesia for rigid bronchoscopy. At the end of the procedure and a twitch of 25% mivacurium was reversed with neostigmine (50 microg/kg) and atropin (10 microg/kg)

Study Status

Completed

Start Date: October 2013

Completed Date:

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Intubating condition

Secondary Outcome: Postoperative Myalgia

Study sponsors, principal investigator, and references

Principal Investigator: Grietje Beck, Prof

Lead Sponsor: Dr. Horst Schmidt Klinik GmbH

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01966484

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