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Intubating Conditions | Comparing Intubating Conditions Using Succinylcholine or Rocuronium for Rigid Bronchoscopy

Intubating Conditions research study

What is the primary objective of this study?

Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application aof rocuronium, reversed by sugammadex. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM) as well as patient satisfaction for these two muscle relaxants.

Who is eligible to participate?

Inclusion Criteria: - age > 18 yr - scheduled for elective rigid bronchoscopy Exclusion Criteria: - known neuromuscular disease - significant hepatic or renal dysfunction - family history of malignant hyperthermia - known allergy to one of the drugs used in this protocol - pregnancy or breastfeeding

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Intubating Conditions

Postoperative Myalgia

Patient Satisfaction

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:SuccinylcholineAnaesthesia is induced and maintained with propofol (1-2 mg/kg) and remifentanil (0,5 µg/kg). The study arm is immobilized and after cleaning the skin a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. After induction of anaesthesia the patient receives muscle relaxant according to the study group.

Drug:Rocuronium 0,3General anaesthesia is induced and maintained with propofol (1-2mg/kg) and remifentanil (0,5µg/kg). The study arm is immobilized and after cleaning the skin a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. The Patient receives the muscle relaxant according to the study group.

Drug:Rocuronium 0,6General anaesthesia is induced and maintained with propofol (1-2mg/kg) and remifentanil (0,5µg/kg). The study arm is immobilized and after cleaning the skin a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. The Patient receives the muscle relaxant according to the study group.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

SuccinylcholineSuccinylcholine 0,5mg/kg as muscle relaxant during induction of anaesthesia for rigid bronchoscopy

Rocuronium 0,3Rocuronium 0,3 mg/kg during induction of anaesthesia for rigid bronchoscopy. At the end of procedure 2mg/kg sugammadex for reversal of neuromuscular block are applied.

Rocuronium 0,6Rocuronium 0,6 mg/kg during induction of anaesthesia for rigid bronchoscopy. At the end of procedure 2mg/kg sugammadex for reversal of neuromuscular block are applied.

Study Status

Suspended

Start Date: August 2015

Completed Date:

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Intubating Condition

Secondary Outcome: Postoperative Myalgia

Study sponsors, principal investigator, and references

Principal Investigator: Grietje Beck, Prof

Lead Sponsor: Dr. Horst Schmidt Klinik GmbH

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01996358

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