Nausea | Inhalation Intervention for Nausea in the Emergency Department
Nausea research study
What is the primary objective of this study?
Randomized controlled trial comparing inhalation of isopropyl alcohol vs placebo (normal saline) pads to treat nausea in emergency department patients.
Who is eligible to participate?
Inclusion Criteria: - age range of 18-65 years of age - complaint of nausea and or vomiting - ability to breathe through nose - ability to read and write English Exclusion Criteria: - allergy to isopropyl alcohol - pregnancy or pregnancy status unknown to subject. Pregnancy test only if part of clinical course. - recent upper respiratory infection - recent intake of cefoperazone, disulfiram, or metronidazole or any other medications that are known produce nausea when exposed to alcohol. - use of antiemetic or psychoactive drug within 24 hours - alcohol abuse - nicotine within last 4 hrs
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Other:Alcohol prep pad groupSubjects inhale scent of alcohol pad
Other:Normal Saline prep padSubjects inhale scent of placebo (normal saline) pads
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Alcohol prep pad groupisopropyl alcohol prep pad
Normal Saline prep padnormal saline prep pad
Start Date: April 2014
Completed Date: June 2015
Primary Outcome: Nausea Verbal Numerical Rating Scale (0-10) at 10 Minutes Post Intervention
Secondary Outcome: Verbal Numerical Rating Scale Pain Score (0-10) at 10 Minutes Post Intervention
Study sponsors, principal investigator, and references
Principal Investigator: Kenneth L Beadle, MPAS, BS
Lead Sponsor: Brooke Army Medical Center
Burleigh-Flayer HD, Gill MW, Strother DE, Masten LW, McKee RH, Tyler TR, Gardiner T. Isopropanol 13-week vapor inhalation study in rats and mice with neurotoxicity evaluation in rats. Fundam Appl Toxicol. 1994 Oct;23(3):421-8.