Postmenopausal Osteoporosis | Study on the microRNA Expression Level in Postmenopausal Osteoporosis
Postmenopausal Osteoporosis research study
What is the primary objective of this study?
The miRNA plays an important regulation role in gene expression, and also closely related to bone metabolism. Previous research found that postmenopausal osteoporosis with kidney Yin deficiency syndrome (POP) is associated with CLCF1 gene. This project proposed by bioinformatics prediction CLCF1 targeted regulation of miRNAs, and use the 3 'UTR dual luciferase report system for target validation, aimed at the miRNA levels to explore postmenopausal osteoporosis molecular mechanism with kidney Yin deficiency syndrome.
Who is eligible to participate?
Inclusion Criteria: - The Participants who volunteer to be test subjects, and can accept experimental drugs, and promise to finish the course should sign the informed consent. - Female ages 45 to 75 had gone through natural menopause before two years - In accordance with the western medicine diagnostic criteria of osteoporosis and belong to kidney Yin deficiency syndrome differentiation of traditional Chinese medicine certificate; - In accordance with the western medicine diagnostic criteria; - In accordance with TCM diagnostic methods; .If any of the above answers are no, The subjects couldn't in the study. Exclusion Criteria: - Do not accord with standard of the western medicine diagnosis and TCM diagnostic methods - Age: <44 and > 76 years old; - With hyperparathyroidism, osteomalacia, rheumatoid arthritis, multiple myeloma and other serious complications such as secondary osteoporosis; Late or deformity, disability, loss of labor; - With cardiovascular, cerebrovascular, liver, kidney and hematopoietic system and other serious primary diseases; - Psychosis or alzheimer's patients; - Nearly three months, the use of hormone replacement therapy (HRT) and taking calcitonin, nearly six months has used double phosphonic acid salt for 15 days, etc.; - This medicine allergic constitution or composition of known to have allergies; - In a critical condition, It's difficult to make exact evaluators to efficacy and safety of the new drugs;
Which medical condition, disease, disorder, syndrome, illness, or injury is researched?
Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.
Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.
Start Date: February 2014
Completed Date: January 2015
Type: Observational [Patient Registry]
Primary Outcome: microRNA expression lever in the Peripheral Blood
Study sponsors, principal investigator, and references
Principal Investigator: FJ ITCM, provincial
Lead Sponsor: Fujian Academy of Traditional Chinese Medicine
McClung MR, Grauer A, Boonen S, Bolognese MA, Brown JP, Diez-Perez A, Langdahl BL, Reginster JY, Zanchetta JR, Wasserman SM, Katz L, Maddox J, Yang YC, Libanati C, Bone HG. Romosozumab in postmenopausal women with low bone mineral density. N Engl J Med. 2014 Jan 30;370(5):412-20. doi: 10.1056/NEJMoa1305224. Epub 2014 Jan 1.