Acute Intentional Overdose | EtCO2 Monitoring in Acute Self-poisoning

Acute Intentional Overdose research study

What is the primary objective of this study?

There is no consensus on monitoring criteria in acute self poisoning. Clinical scores, vital signs or lactatemia have failed to prove good predictive value. The main acute self poisoning complication is decreased consciousness level with consequent increased risk of hypoxemia and aspiration pneumonitis. Several clinical studies have recently shown that EtCO2 monitoring can be valuable in procedural sedation in the emergency department. It is able to predict hypoxemia before any SaO2 decrease and any complications related to these procedures. We therefore hypothesized that EtCO2 could help in acute self poisoning patients' monitoring in the ED.

Who is eligible to participate?

Inclusion Criteria: - >18y/o - acute self poisoning patients - patients requiring monitoring according to physician's opinion - patients not requiring invasive ventilation at ED admission Exclusion Criteria: - Pregnant woman - patients deprived of liberty

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Acute Intentional Overdose

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Acute poisoningConsecutive acute drug self poisoned patients admitted in the ED.

Study Status

Unknown status

Start Date: March 2012

Completed Date:


Type: Observational


Primary Outcome: ROC curve of maximal EtCO2 to predict poisoning complication

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: University Hospital, Grenoble


More information:

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