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Bronchiolitis | Study of High-flow Oxygen Therapy Against Standard Therapy in Bronchiolitis

Bronchiolitis research study

What is the primary objective of this study?

Bronchiolitis is a common illness of the respiratory tract caused by infection of the tiny airways within the lungs called bronchioles. At present the standard care of hospitalized children with bronchiolitis is oxygen via nasal prongs. In this study the investigators would like to compare standard ward management with a new method of delivering oxygen called high flow nasal cannula oxygen therapy (HFNOT). HFNOT involves breathing warmed, moistened oxygen through nasal cannulae at a flow rate of 8 liters/minute. Accumulated experience suggests that HFNOT eases the child's work of breathing and reduces need for ICU admission and invasive respiratory support.

Who is eligible to participate?

Inclusion Criteria: - All children under 18 months of age with a clinical diagnosis of bronchiolitis requiring admission to hospital for observation and oxygen. Exclusion Criteria: - Infants admitted directly to ICU from Emergency. - Prior positive pressure home ventilation. - Tracheostomy. - Nasogastric tubes in situ on admission. - Upper airway abnormality. - Congenital heart disease.

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Bronchiolitis

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Procedure:High Flow Nasal Cannula Oxygen TherapyWarm humidified oxygen will be delivered at 8 liters/minute via nasal cannulae, at a concentration that maintains saturations greater than 92%.

Other:Standard low flow oxygenStandard low flow oxygen will be given to patients to maintain saturations greater than 92%.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

ControlStandard low-flow oxygen therapy.

InterventionHigh Flow Nasal Cannula Oxygen Therapy

Study Status

Completed

Start Date: December 2011

Completed Date: December 2014

Phase: N/A

Type: Interventional

Design:

Primary Outcome: Length of hospital stay

Secondary Outcome: Admission to Intensive Care Unit

Study sponsors, principal investigator, and references

Principal Investigator: David Wensley, MD

Lead Sponsor: University of British Columbia

Collaborator:

More information:https://clinicaltrials.gov/show/NCT01498094

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