Cardiac Arrest | Registry of Unexplained Cardiac Arrest

Cardiac Arrest research study

What is the primary objective of this study?

The CASPER will collect systematic clinical assessments of patients and families within the multicenter Canadian Inherited Heart Rhythm Research Network. Unexplained Cardiac Arrest patients and family members will undergo standardized testing for evidence of primary electrical disease and latent cardiomyopathy along with clinical genetics screening of affected individuals based on an evident or unmasked phenotype.

Who is eligible to participate?

Inclusion Criteria: - Cardiac arrest requiring cardioversion or defibrillation. - Syncope with documented polymorphic ventricular tachycardia felt to be responsible for the index event. - First degree relative of an index case of UCA undergoing clinical testing. - First degree relative of a family member with UCA or sudden death before age 35 with a negative autopsy for cause of death, presumed arrhythmic. - First degree relative of a family member with UCA or sudden death with objective evidence of primary electrical disease, such as a diagnostic electrocardiogram (ECG), exercise test, drug infusion, or genetic testing. Exclusion Criteria: - Coronary artery disease (stenosis > 50%) - Reduced left ventricular function (left ventricular ejection fraction [LVEF] < 50%) - Event managed without an implantable cardioverter defibrillator [ICD] (for follow-up portion) - Unwilling or unable to provide clinical follow-up (for follow-up portion) - Comorbidity making survival of > 1 year unlikely - Persistent resting QTc > 460 msec for males and 480 msec for females - Reversible cause of cardiac arrest such as marked hypokalemia (< 2.8 mmol/l) or drug overdose sufficient in gravity without other cause to explain the cardiac arrest - Hemodynamically stable sustained monomorphic ventricular tachycardia with a QRS morphology consistent with recognized forms of idiopathic ventricular tachycardia (outflow tract or apical septal) - Brugada's sign with e2 mm ST elevation in V1 and/or V2 - Unwilling or unable to provide consent

Which medical condition, disease, disorder, syndrome, illness, or injury is researched?

Cardiac Arrest

Long QT Syndrome

Brugada Syndrome

Catecholaminergi Polymorphic Ventricular Tachycardia

Idiopathic VentricularFibrillation

Early Repolarization Syndrome

Arrhythmogenic Right Ventricular Cardiomyopathy

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

Cardiac Arrest Survivors or Post Mortem Unexplained CardiacProbands - Unexplained Cardiac Arrest Survivors and Post Mortem Unexplained Cardiac Arrest Cases

First Degree Family MembersFirst Degree Family Members of those affected by Sudden Unexplained Cardiac Arrest

Study Status


Start Date: May 2004

Completed Date: January 2027


Type: Observational


Primary Outcome: Developing and Testing Algorithms for Diagnostics and Treatments in Survivors of Unexplained Cardiac Arrest

Secondary Outcome:

Study sponsors, principal investigator, and references

Principal Investigator: Andrew D Krahn, MD

Lead Sponsor: University of British Columbia

Collaborator: Heart and Stroke Foundation of Ontario

More information:

Krahn AD, Gollob M, Yee R, Gula LJ, Skanes AC, Walker BD, Klein GJ. Diagnosis of unexplained cardiac arrest: role of adrenaline and procainamide infusion. Circulation. 2005 Oct 11;112(15):2228-34. Epub 2005 Oct 3.

Krahn AD, Healey JS, Chauhan V, Birnie DH, Simpson CS, Champagne J, Gardner M, Sanatani S, Exner DV, Klein GJ, Yee R, Skanes AC, Gula LJ, Gollob MH. Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER). Circulation. 2009 Jul 28;120(4):278-85. doi: 10.1161/CIRCULATIONAHA.109.853143. Epub 2009 Jul 13. Erratum in: Circulation. 2010 Jun 29;121(25):e460.

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